Design of Noncanonical Alpha-Helices

Alpha-helices are fundamental structural elements in proteins, crucial in stability and function. While nature primarily relies on canonical alpha-helices, advancements in computational protein design and synthetic biology enable the creation of noncanonical helices with enhanced stability, novel binding capabilities, and…

AI-for-healthcare-allosteric-proteins

Morphing protein assemblies by design

This blog post originally published on Baker’s Lab details significant advances in designing protein assemblies capable of precise conformational changes under allosteric control. This groundbreaking research, published in Nature, represents a major step forward in synthetic biology and protein engineering…

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Neutralizing deadly snake toxins

The blog post originally published on Baker’s Lab details an innovative breakthrough in addressing one of the world’s most neglected tropical health crises: snakebite envenomation. According to data cited in the post, the World Health Organization estimates that venomous snakes…